只處理皮膚病灶就可以了嗎？普查近七萬名異位性皮膚炎病童：先合併新生兒熱痙攣、便祕、氣喘，接著是食物過敏、過敏性鼻炎、身心症、自體免疫疾病 - 韓國研究

本篇研究，“Cascade of atopic dermatitis comorbidities in children after birth for 15 years”，請見這裡（外部網站），期刊摘要如下：

Background：

Individuals with atopic dermatitis often develop other conditions.

Objective：

This study aimed to determine how atopic dermatitis comorbidities develop in children over time.

Methods：

This population-based administrative cohort study used national health insurance data. We traced individuals born in Korea between 2002 and 2003 to 2018.

The date of initial atopic dermatitis diagnosis was set as the index date. Fifty-three childhood comorbidities of atopic dermatitis were identified as outcomes of interest by performing a comprehensive literature search and comparing the prevalence of diagnostic codes in children with and without atopic dermatitis.

Four control children per individual in the atopic dermatitis group were randomly matched based on sex and index date.

The association between atopic dermatitis and the development of each specified disease was assessed using proportional hazard assumption, followed by mapping of the temporal sequences of interconnected comorbidities.

Results：

The atopic dermatitis and control groups contained 67,632 and 270,528 individuals, respectively. The median age at the index date was 10 months, whereas the median follow-up period was 15 years.

Twenty diseases that were associated with a higher risk of atopic dermatitis were identified and a chain of interconnected conditions created.

The progression began in childhood with febrile seizures, constipation, and asthma, and was later associated with the emergence of food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.

Conclusion：

Our study highlights the temporal nature of atopic dermatitis comorbidities in children, and indicates that an understanding of the comorbidities may inform its clinical management and treatment.

原始論文

Cascade of atopic dermatitis comorbidities in children after birth for 15 years（外部網站）

Kim JH, Lee E, Ha EK, Shin J, et al. Allergy. 2024;79(1):153-163. doi:10.1111/all.15917

論文摘要（Google 翻譯）

以下為 Google 翻譯，並校正明顯錯誤，僅供參考，內容以英文原文為準。

兒童出生後 15 年間異位性皮膚炎共病的連鎖發展

背景：異位性皮膚炎患者常會發生其他疾病。

目的：本研究旨在釐清兒童的異位性皮膚炎共病如何隨時間發展。

方法：這項以族群為基礎的行政資料世代研究使用全民健康保險資料。我們追蹤 2002 年至 2003 年間在韓國出生的個體，直到 2018 年。

以首次診斷異位性皮膚炎的日期作為指標日期。經由全面的文獻檢索，並比較有無異位性皮膚炎兒童之診斷代碼盛行率，確立 53 種兒童期異位性皮膚炎共病作為關注的結果。

異位性皮膚炎組的每一名個體，依性別與指標日期隨機配對四名對照兒童。

以比例風險假設評估異位性皮膚炎與各特定疾病發生之間的關聯，並接著描繪相互關聯之共病的時間順序。

結果：異位性皮膚炎組與對照組分別有 67,632 人與 270,528 人。指標日期的年齡中位數為 10 個月，追蹤期中位數為 15 年。

研究找出 20 種與異位性皮膚炎相關、風險較高的疾病，並建立一連串相互關聯的疾病鏈。

此進展始於兒童期的熱性痙攣、便秘與氣喘，之後則與食物過敏、過敏性鼻炎、精神疾病及自體免疫疾病的出現相關。

結論：本研究凸顯兒童異位性皮膚炎共病的時間性，並顯示了解這些共病有助於其臨床處置與治療。

異位性皮膚炎，中醫經方的治療實例，請見這裡。

小兒異位性皮膚炎，中醫經方的治療實例，請見這裡。

成人異位性皮膚炎，中醫經方的治療實例，請見這裡。

異位性皮膚炎，期刊研究，請看這裡。

期刊研究整理，請見這裡。