家黃于家醫師家中醫診所

期刊研究整理文/黃于家醫師

只處理皮膚病灶就可以了嗎?普查三萬名兒童異位性皮膚炎患者:受苦的不只是皮膚,多會合併其它疾患,如氣喘、過敏性鼻炎、身心症、腸躁症

J Clin Med 論文摘要:西班牙三萬多名異位性皮膚炎兒童的共病研究

異位性皮膚炎往往不只皮膚出問題,多會合併其它疾患,皮膚病況嚴重者更是如此,而且皮膚問題事實上與腸道密切相關。

異位性皮膚炎時常合併睡眠障礙、消化問題、氣喘、過敏性鼻炎、身心症,而正值青春期的患者又須考量長高發育等。

不只能治療皮膚,還同步處理多個身體不適,讓皮膚達到從裡到外的改變,正是中醫所擅長的。

畢竟皮膚有問題,有其內在的原因。

異位性皮膚炎需要認真看待,當患者長時間睡不好,會容易情緒低落、焦慮易怒,皮膚狀況不穩定也可能導致社交困難,甚至霸凌或自我封閉,這些骨牌效應影響深遠,不可不慎。

“Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data(外部網站)”,期刊摘要如下:

This study aimed at exploring atopic dermatitis(AD)prevalence in children and exhaustively analyzing their comorbidity. We conducted a descriptive analysis of their socio-demographic and comorbidity characteristics in the EpiChron Cohort(Aragón, Spain). Adjusted odds ratios(OR)were calculated for each comorbidity using logistic regression models.

In total, 33,591 children had a diagnosis of AD, resulting in an overall prevalence of 15.5%. AD prevalence was higher in girls compared to boys, in 3–9-year-olds compared to children of other ages, and in Spanish children compared to those of other nationalities.

Multimorbidity was present in 43% of children, with the most frequent chronic comorbidities being asthma(13.1%), psychosocial disorders(7.9%), and visual impairment(7.8%).

Many diseases were, regardless of their prevalence, statistically associated with AD. The strongest associations(odds ratio(OR)(95% confidence interval(CI)))were found in asthma(2.10(2.02–2.17)), allergic rhinitis(2.00 (1.91–2.10)), and irritable bowel syndrome(1.90(1.56–2.31)).

A better understanding of the array of comorbidities associated with AD in children might help improve their clinical management. Future longitudinal studies are encouraged to shed light on the potential underlying pathophysiological mechanisms involved in the identified associations.

原始論文

Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data(外部網站)

Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, et al. Journal of Clinical Medicine. 2020;9(6):1632. doi:10.3390/jcm9061632

論文摘要(Google 翻譯)

以下為 Google 翻譯,並校正明顯錯誤,僅供參考,內容以英文原文為準。

兒童異位性皮膚炎的盛行率與共病:一項以真實世界資料為基礎的大規模族群研究

本研究旨在探討兒童異位性皮膚炎(AD)的盛行率,並全面分析其共病。我們在 EpiChron 世代(西班牙亞拉岡)中,對其社會人口學與共病特徵進行描述性分析,並以邏輯斯迴歸模型計算各項共病的校正勝算比(OR)。

共有 33,591 名兒童被診斷為 AD,整體盛行率為 15.5%。女孩的 AD 盛行率高於男孩,3–9 歲兒童高於其他年齡層,西班牙籍兒童高於其他國籍的兒童。

43% 的兒童有多重疾病,最常見的慢性共病為氣喘(13.1%)、心理社會疾患(7.9%)與視力障礙(7.8%)。

許多疾病無論盛行率高低,都與 AD 有統計上的關聯。關聯最強的(勝算比(OR)(95% 信賴區間(CI)))是氣喘(2.10(2.02–2.17))、過敏性鼻炎(2.00(1.91–2.10))與腸躁症(1.90(1.56–2.31))。

更了解與兒童 AD 相關的各種共病,可能有助於改善其臨床處置。鼓勵未來進行縱向研究,以釐清這些關聯背後可能的病理生理機制。

期刊全文,請見這裡(外部網站)。

異位性皮膚炎,中醫經方的治療實例,請見這裡。

小兒異位性皮膚炎,中醫經方的治療實例,請見這裡。

成人異位性皮膚炎,中醫經方的治療實例,請見這裡。

異位性皮膚炎,期刊研究,請看這裡。

其他期刊研究整理,請見這裡。

原文發表於 作者部落格(舊部落格)。

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