異位性皮膚炎多合併氣喘、過敏性鼻炎和食物過敏，特別是一歲前就發病、病情較重、有家族史的男童

異位性皮膚炎，中醫經方的治療實例，請見這裡。

小兒異位性皮膚炎，中醫經方的治療實例，請見這裡。

成人異位性皮膚炎，中醫經方的治療實例，請見這裡。

異位性皮膚炎，期刊研究，請看這裡。

期刊研究整理，請見這裡。

本篇研究，Risk factors and temporal associations of progression of the atopic march in children with early-onset atopic dermatitis，請見這裡（外部網站）。

Background：

Risk factors and the temporal relationship between atopic dermatitis (AD) and atopic march remain understudied.

Objective：

Determine risk factors for atopic march in early-onset AD patients and the temporality between AD and atopic march.

Methods：

We used the MarketScan Research Database for our retrospective cohort analysis from 2010 to 2018, comparing infants diagnosed with AD before age 1 with controls without early-onset AD. Primary outcomes were hazard ratios (HRs) for the development of asthma, allergic rhinitis, and food allergy.

Results：

Compared to 55,174 controls, higher proportions of the 27,228 AD patients developed asthma (19.21% vs 8.65%, P < .001), allergic rhinitis (28.27% vs 12.62%, P < .001), food allergy (16.00% vs 2.27%, P < .001), and all atopic triad conditions (10.69% vs 0.71%, P < .001). Among AD patients, higher proportions developed the atopic triad if they were male (HR 1.66, 95% confidence interval [1.45-1.90]), had severe disease (HR 3.16, [2.77-3.60]), or had family atopy history (HR > 3.40, P < .001 for all comparisons). Among AD patients, 20.1% developed allergic rhinitis.

Limitations：

Our study was based on health care claims data.

Conclusion：

Early-onset AD is associated with higher rates of developing atopic march conditions compared to controls. Particular attention should be paid toward risk factors and atopic march screening in early-onset AD patients.

原始論文

Risk factors and temporal associations of progression of the atopic march in children with early-onset atopic dermatitis（外部網站）

Choi UE, Deng J, Parthasarathy V, Liao V, et al. Journal of the American Academy of Dermatology. 2025;92(4):732-740. doi:10.1016/j.jaad.2024.10.107

論文摘要（Google 翻譯）

以下為 Google 翻譯，並校正明顯錯誤，僅供參考，內容以英文原文為準。

早發性異位性皮膚炎兒童過敏進行曲進展的危險因子與時間關聯

背景：異位性皮膚炎（AD）與過敏進行曲（atopic march）之間的危險因子與時間關係，仍缺乏充分研究。

目的：找出早發性 AD 患者發生過敏進行曲的危險因子，以及 AD 與過敏進行曲之間的時間先後關係。

方法：我們使用 MarketScan 研究資料庫進行 2010 年至 2018 年的回溯性世代分析，比較 1 歲前被診斷為 AD 的嬰兒與無早發性 AD 的對照組。主要結果為發生氣喘、過敏性鼻炎與食物過敏的風險比（HR）。

結果：與 55,174 名對照者相比，27,228 名 AD 患者中發生氣喘（19.21% 對 8.65%，P < .001）、過敏性鼻炎（28.27% 對 12.62%，P < .001）、食物過敏（16.00% 對 2.27%，P < .001），以及三種過敏疾病全部發生（10.69% 對 0.71%，P < .001）的比例較高。在 AD 患者中，男性（HR 1.66，95% 信賴區間［1.45–1.90］）、疾病嚴重（HR 3.16，［2.77–3.60］）或有家族過敏史（HR > 3.40，所有比較 P < .001）者，發生三種過敏疾病的比例較高。AD 患者中有 20.1% 發生過敏性鼻炎。

限制：本研究以醫療保險理賠資料為基礎。

結論：與對照組相比，早發性 AD 與較高的過敏進行曲疾病發生率相關。對早發性 AD 患者，應特別留意危險因子並進行過敏進行曲篩檢。