異位性皮膚炎長大就會好？韓國延世大學醫院五千位患者研究：成人占一半，病情會比年幼患者嚴重，頭頸部病灶多，壓力會惡化

本篇研究，“Clinical Diversity of Atopic Dermatitis: A Review of 5,000 Patients at a Single Institute”，請見這裡（外部網站），期刊摘要如下：

Purpose

Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD.

Methods

This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea.

Results

The demographics, allergic comorbidities, family history, severity, and treatment experiences of the patients were analyzed.

Most of the patients were adults, 76.3% of whom were classified as havingan extrinsic type of AD.

The mean eczema area and severity index (EASI) score was found to be 13.68, and adult patients were found to have higher severity than the other age groups.

The anatomical involvements were different among the age groups, with more involvements of the head and neck in adults.

The patients reported seasonal changes and stress as the factors that aggravated their symptoms the most.

Topical steroids and oral cyclosporine were the most used medications at our clinic, whereas 10.1% of the patients underwent allergen-specific immunotherapy.

Conclusions

This analysis of 5,000 patients would lead to a better understanding of various subtypes and diverse clinical features of AD in Koreans.

Distinct characteristics were observed among different age groups; thus, treatment strategies may need to be differentiated accordingly.

原始論文

Clinical Diversity of Atopic Dermatitis: A Review of 5,000 Patients at a Single Institute（外部網站）

Chu H, Shin JU, Park CO, Lee H, et al. Allergy, Asthma & Immunology Research. 2017;9(2):158-168. doi:10.4168/aair.2017.9.2.158

論文摘要（Google 翻譯）

以下為 Google 翻譯，並校正明顯錯誤，僅供參考，內容以英文原文為準。

異位性皮膚炎的臨床多樣性：單一醫療機構 5,000 名患者的回顧

目的：異位性皮膚炎（AD）是一種盛行率高、臨床表現多樣的慢性濕疹性皮膚炎。雖然已有數種關於其多因子致病機轉的假說，但病因仍未完全明瞭。更了解其臨床特徵，可能有助於闡明 AD 的致病機轉。

方法：這項回溯性研究分析韓國一家三級醫院 5,000 名 AD 確診患者的問卷、病歷與實驗室檢查結果。

結果：分析患者的人口學資料、過敏共病、家族史、嚴重度與治療經驗。

大多數患者為成人，其中 76.3% 被歸類為外因性 AD。

平均濕疹面積與嚴重度指數（EASI）分數為 13.68，成人患者的嚴重度高於其他年齡層。

各年齡層的受侵犯部位不同，成人較常侵犯頭頸部。

患者表示，季節變化與壓力是最會使症狀加重的因素。

外用類固醇與口服環孢素是本院最常使用的藥物，另有 10.1% 的患者接受過敏原特異性免疫治療。

結論：這項針對 5,000 名患者的分析，將有助於更了解韓國人 AD 的各種亞型與多樣的臨床特徵。

不同年齡層觀察到不同特徵；因此，治療策略可能需要依此區分。

如果你曾經聽過「異位性皮膚炎長大就會自己好」，下面這位患者的經驗，值得一起閱讀。

異位性皮膚炎患者，血淚經驗分享：「我很希望它好起來，但怎麼樣都好不了，只剩下相信長大會自己好的希望」。

異位性皮膚炎，期刊研究，請看這裡。

期刊研究整理，請見這裡。

異位性皮膚炎，中醫經方的治療實例，請見這裡。