戒煙可降低乾癬的發生率和嚴重度，搭配減重效果更好 - 韓國研究

本篇研究，“Dual impact of smoking cessation and post-cessation weight change on psoriasis”，請見這裡（外部網站），期刊摘要如下：

Background：

The impact of post-cessation weight changes on the preventive effect of smoking cessation on psoriasis remains unknown.

Objectives：

To examine the association between smoking cessation, subsequent weight changes measured using body mass index (BMI), risks of psoriasis vulgaris (PsV), palmoplantar pustulosis (PPP) and generalized pustular psoriasis (GPP).

Methods：

This nationwide cohort study, performed using the Korean National Health Insurance Service database, included 5,470,955 participants who underwent two consecutive biennial health screenings from 2004 to 2005 and 2006 to 2007.

Data on changes in smoking habits and BMI status were obtained from these health screenings. The Cox proportional hazards model was utilized to estimate the risk of developing psoriasis based on changes in smoking habits and weight status.

Results：

Over 73.7 million person-years, 63,538 cases of psoriasis were identified, including 49,157 PsV, 9291 PPP and 2298 GPP cases. Smoking quitters without weight changes (adjusted hazard ratio [aHR] 0.85; 95% confidence interval [CI] 0.79-0.92) and those with weight loss (aHR 0.88; 95% CI 0.79-0.97) showed a lower risk of psoriasis, including PsV and PPP, compared to sustained smokers.

However, post-cessation weight gain attenuated the benefits of smoking cessation, particularly for PsV. Nevertheless, the protective effect of smoking cessation on PPP remained substantial even in quitters with weight gain (aHR 0.67; 95% CI 0.57-0.79).

In sensitivity analyses considering the time-varying characteristics of smoking status and weight changes and examining the long-term effects of smoking cessation, a notable decrease in the risk of psoriasis, including PsV and PPP, was identified regardless of post-cessation weight change.

Conclusions：

Despite post-cessation weight gain, smoking cessation should be encouraged to prevent psoriasis, and weight management is recommended to maximize the health benefits of quitting smoking for psoriasis.

原始論文

Dual impact of smoking cessation and post-cessation weight change on psoriasis（外部網站）

Kim SR, Choi YG, Jo SJ. Journal of the European Academy of Dermatology and Venereology. 2026;40(2):285-295. doi:10.1111/jdv.70168

論文摘要（Google 翻譯）

以下為 Google 翻譯，並校正明顯錯誤，僅供參考，內容以英文原文為準。

戒菸及戒菸後體重變化對乾癬的雙重影響

背景：戒菸後的體重變化，對戒菸預防乾癬效果的影響仍不清楚。

目的：探討戒菸、戒菸後以身體質量指數（BMI）衡量的體重變化，與尋常性乾癬（PsV）、掌蹠膿皰症（PPP）及全身性膿皰型乾癬（GPP）風險之間的關聯。

方法：這項全國性世代研究使用韓國國民健康保險公團資料庫，納入 5,470,955 名在 2004–2005 年與 2006–2007 年連續接受兩次每兩年一次健康檢查的參與者。

吸菸習慣與 BMI 狀態的變化資料取自這些健康檢查。以 Cox 比例風險模型，依吸菸習慣與體重狀態的變化估計發生乾癬的風險。

結果：在超過 7370 萬人年的追蹤中，共發現 63,538 例乾癬，包括 49,157 例 PsV、9291 例 PPP 與 2298 例 GPP。與持續吸菸者相比，戒菸後體重無變化者（校正風險比［aHR］0.85；95% 信賴區間［CI］0.79–0.92）與體重減輕者（aHR 0.88；95% CI 0.79–0.97），發生乾癬（包括 PsV 與 PPP）的風險較低。

然而，戒菸後體重增加會削弱戒菸的益處，尤其是對 PsV。儘管如此，即使是體重增加的戒菸者，戒菸對 PPP 的保護效果依然明顯（aHR 0.67；95% CI 0.57–0.79）。

在考量吸菸狀態與體重變化隨時間變動的特性、並檢視戒菸長期效果的敏感性分析中，無論戒菸後體重如何變化，乾癬（包括 PsV 與 PPP）的風險都明顯下降。

結論：即使戒菸後體重增加，仍應鼓勵戒菸以預防乾癬，並建議進行體重管理，使戒菸對乾癬的健康益處最大化。

乾癬，中醫經方的治療實例，請見這裡。

乾癬，期刊研究，請看這裡。

期刊研究整理，請見這裡。