乾癬與高鹽飲食有關，吃越鹹，乾癬發生風險越高 - 英國研究

本篇研究，“Increased sodium consumption is associated with psoriasis: A population-based cohort study”，請見這裡（外部網站），期刊摘要如下：

Background：

Sodium is stored in skin and may trigger or perpetuate autoimmune diseases including psoriasis.

One previous study found skin sodium was elevated in a small group of patients with severe psoriasis compared to healthy controls, but the relationship between sodium intake and psoriasis within a population has not been investigated.

Objectives：

To identify whether dietary sodium intake is associated with psoriasis and whether there are subgroups of individuals more likely to have salt-sensitive psoriasis.

Methods：

This cross-sectional, population-based study evaluated a UK Biobank cohort of nearly 500,000 participants in the 2006-2010 period and a US-based National Health and Nutrition Examination Survey (NHANES) validation cohort of 2393 participants in the 2003-2004 period.

Dietary sodium intake, the exposure, was estimated using urine biomarkers and the previously validated INTERSALT equation. Psoriasis outcome was assessed by the presence of ICD-10 code L40.

Results：

In the UK Biobank, of the 468,913 included participants, 54% were female and mean (standard deviation) age at recruitment was 57 (8) years.

Multivariable logistic regression models revealed that every 1 g increase in estimated 24-h urine sodium was associated with an 18% increase in odds of psoriasis (OR 1.18, 95% CI: 1.14-1.21) after adjustment for sex, age, race/ethnicity, education and socioeconomic status.

There was no consistent evidence of large effect modification by age, sex, race/ethnicity, polygenic risk score for psoriasis or those with a history of hypertension, chronic renal failure or type 2 diabetes mellitus.

In NHANES, each additional gram of self-reported dietary sodium intake was also associated with increased odds of examination-confirmed psoriasis (OR: 1.47, 95% CI: 1.19-1.83).

Conclusions：

Increased sodium intake was associated with psoriasis in two population-based cohorts; future clinical trials could investigate whether decreasing sodium intake improves psoriasis.

原始論文

Increased sodium consumption is associated with psoriasis: A population-based cohort study（外部網站）

Chattopadhyay A, Ye M, Chiang B, Halezeroglu Y, et al. Journal of the European Academy of Dermatology and Venereology. 2025;39(9):1622-1630. doi:10.1111/jdv.20540

論文摘要（Google 翻譯）

以下為 Google 翻譯，並校正明顯錯誤，僅供參考，內容以英文原文為準。

鈉攝取增加與乾癬相關：一項以族群為基礎的世代研究

背景：鈉會儲存在皮膚中，並可能誘發或延續包括乾癬在內的自體免疫疾病。

先前一項研究發現，一小群重度乾癬患者的皮膚鈉含量高於健康對照者，但在族群中，鈉攝取量與乾癬之間的關係尚未被研究。

目的：確認飲食鈉攝取是否與乾癬相關，以及是否有某些次族群較可能出現鹽敏感型乾癬。

方法：這項以族群為基礎的橫斷面研究，評估 2006–2010 年間近 50 萬名參與者的英國生物資料庫（UK Biobank）世代，以及 2003–2004 年間 2393 名參與者的美國國家健康與營養檢查調查（NHANES）驗證世代。

飲食鈉攝取量（即暴露因子）以尿液生物標記及先前已驗證的 INTERSALT 公式估算。乾癬結果以是否有 ICD-10 代碼 L40 判定。

結果：英國生物資料庫納入的 468,913 名參與者中，54% 為女性，收案時平均（標準差）年齡為 57（8）歲。

多變項邏輯斯迴歸模型顯示，在校正性別、年齡、種族／族裔、教育程度與社經地位後，估計的 24 小時尿鈉每增加 1 公克，罹患乾癬的勝算增加 18%（OR 1.18，95% CI：1.14–1.21）。

沒有一致證據顯示年齡、性別、種族／族裔、乾癬多基因風險分數，或有高血壓、慢性腎衰竭、第 2 型糖尿病病史者，會產生大幅的效應修飾。

在 NHANES 中，自述的飲食鈉攝取量每多 1 公克，也與經檢查確認的乾癬勝算增加相關（OR：1.47，95% CI：1.19–1.83）。

結論：在兩個以族群為基礎的世代中，鈉攝取增加與乾癬相關；未來的臨床試驗可探討減少鈉攝取是否能改善乾癬。

乾癬，中醫經方的治療實例，請見這裡。

乾癬，期刊研究，請看這裡。

期刊研究整理，請見這裡。